Cut the persimmons into quarters. Peel the lemon. Using a juicer, juice the persimmons, lemon flesh and ginger.
For each cocktail, combine 4 ounces of the juice mixture, 1 teaspoon of agave nectar, 1½ ounces of vodka and the vanilla bean in a cocktail shaker with ice. Strain into a chilled martini glass. Garnish with the vanilla bean.
Note: If you do not have a juicer, mash fruit together and strain.
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